Tel Aviv has a modern, regular and widespread bus network run mostly by a company called Dan. Bus services start at 05:00 and stop at midnight, though some of the lines stop earlier. Single tickets within the city and the close suburbs (Bat Yam, Holon, Ramat Gan, Bney Brak, Givatayim) cost 5.20 NIS, around 1.3US$. Daily free-pass called "Hofshi-Yomi" is also available, and cost less than the price of three rides. There is also 10-rides ticket (which cost the equivalent of 8 single tickets, so offering 20% discount) which could be used by several passengers. Tickets can be purchased either at the driver of any bus line, or at the New Central Bus Station. Exact change is not necessary, but a driver may refuse payment by notes of 100 or 200 Shekels.

Suburban lines are also operated by Egged (mainly to the southern suburbs) and Kavim (to Kiryat Ono region) companies. Multi-ride tickets are not exchangeable between companies.

The most popular bus route in the city is bus route number 5, which connects the Central Bus Station (departure from 4th floor, westernmost platform) in the south with the Central Train Station. It goes through Rotschild Boulevards, Dizengof Street (Including the Dizengof Center Mall), Nordau boulevard, Pinkas/Yehuda Maccabi street and Weizman Street or Namir road. Another popular bus route is number 18, connecting the Central Train Station with the southern neighbourhoods of Jaffa and Bat-Yam. It also has a stop in Rabin Square.

Like most Israelis, the bus drivers in Tel Aviv speak and understand English well, and in most cases will kindly answer questions about the destination of their bus.